What is the blood gas partition coefficient for Isoflurane?

The blood gas partition coefficient for Isoflurane is 1.46. This coefficient is a key pharmacological parameter that indicates the solubility of the anesthetic agent in blood compared to its presence in the alveolar gas. A higher blood gas partition coefficient means that the agent is more soluble in blood, leading to a slower induction and recovery from anesthesia. Isoflurane, with a coefficient of 1.46, is relatively more soluble in blood than some other anesthetics, which is important for clinicians when considering the speed of onset and offset of anesthesia during surgical procedures.

This value reflects how Isoflurane behaves pharmacokinetically, informing choices regarding dosage and timing when used in clinical practice. Knowing this coefficient helps practitioners predict how long it will take for Isoflurane to reach effective concentrations in the bloodstream and how quickly patients might emerge from anesthesia once administration is halted.

The other values do not accurately represent the blood gas partition coefficient for Isoflurane, reinforcing the importance of understanding these parameters when selecting anesthetics for specific clinical scenarios.