What symptom is associated with hypotension in carcinoid syndrome?

In carcinoid syndrome, a common and notable symptom associated with hypotension is diarrhea. Carcinoid syndrome occurs due to the secretion of serotonin and other vasoactive substances from neuroendocrine tumors, particularly those originating in the gastrointestinal tract. When these substances are released into the systemic circulation, they can lead to various clinical effects, including vasodilation, which may result in hypotension.

Diarrhea is specifically prominent in carcinoid syndrome due to the excess serotonin, which increases gut motility. This frequent and sometimes severe diarrhea often leads to fluid depletion and electrolyte imbalances, further compounding the risk of hypotension. As such, the connection between hypotension and diarrhea is well established in the context of carcinoid syndrome, as the mechanisms driving both symptoms are linked through the pathological processes associated with the release of serotonin and its effects on vascular tone and gastrointestinal function.